Ataxia is feeling of imbalance, lack of coordination lack of control during movement, it is a manifestation of many neurological disease which are hereditary as well as non-hereditary like conditions such as SCA1, SCA2, SCA3 (Machado-Joseph Ataxia), SCA6, Friedreich Ataxia and Ataxia caused by brain injury, sensory ataxia etc
Stem cells have been used to treat patients diagnosed with Ataxia since 2007. Over the last few years different types of Ataxia were treated, such as SCA1, SCA2, SCA3 (Machado-Joseph Ataxia), SCA6, Friedreich Ataxia and Ataxia disorders caused by brain injury. Patients with Ataxia see their condition getting progressively worse because of the constant loss of nerve cells in their brain/spinal cord. Thus, the aim of therapy for Ataxia is to regenerate patient’s lost nerve cells and restore there lost function by using stem cell transplantation. To do so, stem cells are injected in great quantity through IVs and lumbar punctures in order to better target the damaged areas.
Many clinical trials have been conducted worldwide to see if Mesenchymal stem cells have potential to improve symptoms of ataxias; the results so far are encouraging with level 4 evidence of safety and efficacy in certain conditions.
Before trying stem cell therapy patients should undergo other standard treatments (if available), they should ask what kind of stem cell is being used and if that particular stem cell is suitable for their disease.