Optic Nerve Atrophy (ONA) Treatment
Optic nerve disorders will impact vision in some way and can affect one or both eyes. The optic nerve contains about a million of small nerve fibers that carries images of what the eye sees to the brain. As nerve fibers become damaged then brain stop receiving vision information in proper way and eyes sight becomes blurred. Optic Nerve Atrophy is also known as optic atrophy and optic neuropathy.
There are small photoreceptor cells of the retina responsible to sense light and transmit impulses to the optic nerve. The optic nerve from each eye carries these impulses to the brain, where visual information is interpreted and that’s how we can able to see.
Loss of vision happens when there is any damage to an optic nerve or damage to its pathways to the brain. Damage to an eye or the visual pathway causes different types of vision loss depending on where the damage occurs.
Disorders of the optic nerve are caused by following two main factors:
- Developmental (genetic or abnormal development)
- Acquired factors (trauma or disease)
Optic Nerve Atrophy Signs and Symptoms:-
- Difficulties with peripheral (side) vision
- A reduction in sharpness of vision
- Abnormal color vision
- A sudden or abrupt loss of vision
- Involuntary movement of the eyes
- Change in the optic disc
Hereditary, Genetic or developmental anomalies of the Optic Nerve
- Congenital optic atrophy is usually hereditary.
- Leber's Hereditary Optic Neuropathy has an unclear mode of inheritance but is suspected of being X-linked. That’s the reason it rarely occurs in women and occurs more commonly in 20-30 year old males.
- Optic Nerve Hypoplasia (ONH) is an undeveloped optic nerve.
Acquired Optic Atrophy
The acquired type of optic atrophy may be due to the reasons as vascular disturbances, result of pressure against the optic nerve, metabolic diseases (e.g., diabetes), trauma, glaucoma, or toxicity (to alcohol, tobacco, or other poisons).
Optic Neuritis (ON)
Optic Neuritis (ON) is also known as optic papillitis and retrobulbar neuritis. The most common cause of Optic Neuritis is multiple sclerosis (MS). Optic neuritis is an inflammation of the optic nerve.
Ischemic optic neuropathy (ION)
It can be a severely blinding disease resulting from loss of the arterial blood supply to the optic nerve (usually in one eye). Ischemic optic neuropathies (IONs) consist mainly two types one is anterior ischemic optic neuropathy (AION) and posterior ischemic optic neuropathy (PION).
Glaucoma is a complex eye disease and second most common cause of blindness in the world that caused by high eye pressure. This is usually a slowly progressing eye disease which damages the optic nerve fibers and can cause a reduction in the visual field. Untreated glaucoma can eventually lead to optic atrophy and blindness.
Vision losses due to optic nerve atrophy are quite complex and multifaceted. Nerve atrophy or ischemic condition (restricted flow of blood) leads to vision impairment. Since eye is a complex organ with many receptors and neurons conducting signals to the brain for processing, constant renewal of cells and neovascularize is an ever ending process. Stem cells present in the region of the eye can renew and repair, but due to certain factors they don’t function or less efficient in regeneration. Stem cells from various sources can overcome these problems. Umbilical Cord Mesenchymal Stem Cells are such cells which can differentiate into nerve cells, neovascularize (formation of blood vessels) and immunomodulate when injected into the affected area.These stem cells activate/differentiate local stem cells and other biological pathways by chemokine activities to form new or repair optic nerve cells through regeneration.
Procedure For Treating Optic Nerve Atrophy in India
Medical intervention includes Intravenous injection (IV), Lumber Puncture (LP) and Retrobulbar (RB) injections. unistem biosciences provides cost effective plans for optic nerve atrophy treatment or progressive vision loss disorders.
*This is just a tentative intervention, injection and cell type may change depending upon the patient condition and subject to doctor’s medical review.
Outcome of the Treatment
Stem cell intervention can bring significant improvements in the vision quality, vision acuity and ease of pain. These improvements may vary from patient to patient and cannot be guaranteed.
Below is a link to the Descriptive Statistical Report on ONH/SOD Cases with Cell Therapy, a subjective follow-up study tracking patient improvements through the first year after therapy. You can view the PDF in your browser and save it to your computer.
Case studies focus on individual patients and detail their therapy and results. We will be updating this section with new case studies as they become available. Simply click on the pictures below to open each case study.
**Use of Stem cells is in evolution phase and categorized non-conventional**